Technology Process of N-[(4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl)carbonyl]glycine
There total 11 articles about N-[(4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl)carbonyl]glycine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl N-[(4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl)carbonyl]glycinate;
With
water; sodium hydroxide;
In
ethanol;
at 20 ℃;
for 0.5h;
In
ethanol; water;
Acidic conditions;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: ammonium acetate; acetic acid / 5 h / Reflux
2.1: potassium carbonate / tetrahydrofuran / 16 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
3.2: 0.5 h
4.1: triethylamine / dichloromethane / 2 h / 20 °C
5.1: potassium carbonate / acetonitrile / 0.5 h / 0 - 10 °C
5.2: 10 h / 20 °C
6.1: sodium ethanolate; ethanol / 1 h / 10 - 20 °C
7.1: potassium hydroxide; water / ethanol / 3 h / Reflux
7.2: pH 6
8.1: 1,4-dioxane / 10 h / 20 °C
9.1: sodium hydride / N,N-dimethyl acetamide / 0.17 h / Inert atmosphere
9.2: 12 h / 120 °C
10.1: triethylamine / toluene / 2 h / Reflux
11.1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C
11.2: Acidic conditions
With
ethanol; ammonium acetate; water; sodium ethanolate; sodium hydride; potassium carbonate; acetic acid; triethylamine; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
1.2: 0.5 h
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / acetonitrile / 0.5 h / 0 - 10 °C
3.2: 10 h / 20 °C
4.1: sodium ethanolate; ethanol / 1 h / 10 - 20 °C
5.1: potassium hydroxide; water / ethanol / 3 h / Reflux
5.2: pH 6
6.1: 1,4-dioxane / 10 h / 20 °C
7.1: sodium hydride / N,N-dimethyl acetamide / 0.17 h / Inert atmosphere
7.2: 12 h / 120 °C
8.1: triethylamine / toluene / 2 h / Reflux
9.1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C
9.2: Acidic conditions
With
ethanol; water; sodium ethanolate; sodium hydride; potassium carbonate; triethylamine; potassium hydroxide; sodium hydroxide;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene; acetonitrile;
![ethyl N-[(4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl)carbonyl]glycinate](/Databaselist/images/loading.webp)
