methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate

Base Information

• Chemical Name: methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate
• CAS No.: 146073-36-1
• Molecular Formula: C₁₅H₁₄N₂O₆S
• Molecular Weight: 350.352
• Mol file: 146073-36-1.mol

Synonyms:methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate

Chemical Property of methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate

There total 1 articles about methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methyl 3-nitropropionate (20497-95-4) + 1-benzenesulfonyl-2-formylpyrrole (86688-93-9) → methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate (146073-36-1)

Guidance literature:

With ammonium acetate; In methanol; at 60 ℃; for 9h;

DOI:10.1248/cpb.40.2344

Reference yield:

methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate (146073-36-1) → 4-(1-Benzenesulfonyl-1H-pyrrol-2-yl)-3-nitro-butyric acid methyl ester

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 0.583333h; Ambient temperature;

DOI:10.1248/cpb.40.2344

Reference yield:

methyl (E)-3-nitro-4-(1-phenylsulfonyl-2-pyrrolyl)-3-butenoate (146073-36-1) → methyl (E)-4-(1-phenylsulfonyl-2-pyrrolyl)-2-butenoate

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol / 0.58 h / Ambient temperature

2: 1.) NaOMe, 2.) TiCl₃, aq. NH₄OAc / 1.) EtOH, RT, 5 min, 2.) EtOH, RT, 3 h

With sodium tetrahydroborate; titanium(III) chloride; ammonium acetate; sodium methylate; In ethanol;

DOI:10.1248/cpb.40.2344

upstream raw materials:

methyl 3-nitropropionate

1-benzenesulfonyl-2-formylpyrrole

Downstream raw materials:

methyl 3-oxo-4-(1-phenylsulfonyl-2-pyrrolyl)butanoate