20497-95-4

Upstream product

• 3395-91-3 Methyl 3-bromopropionate 
• 186581-53-3 diazomethane 
• 504-88-1 3-nitropropionic acid 
• 67-56-1 methanol 
• 292638-85-8 acrylic acid methyl ester 
• 5199-50-8 methyl 2-iodoacetate 

Downstream Products

• 50692-78-9 methyl 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate 
• 63819-86-3 Methyl 3-nitro-2-(3-oxocyclohexyl)propanoate 
• 63819-85-2 (RS)-2-benzyl-3-nitropropanoic acid methyl ester 
• 82588-83-8 methyl 3-hydroxy-2-(nitromethyl)-3-phenylpropanoate 
• 82266-95-3 (+)-lyxo-3-(Benzoylamino)-2,3,6-trideoxyhexanoic acid γ-lactone 
• 76512-86-2 3-benzoylamino-2,3,6-trideoxyhexono-L-ribo-γ-lactone 
• 82588-86-1 Methyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(nitromethyl)propanoate 
• 1165952-91-9 cyclohexa-1,3-diene 
• 2518-53-8 hexyl-5 (5H) furannone-2 
• 30336-14-2 5-butylfuran-2(5H)-one 
• 591-11-7 5-methyl-5H-furan-2-one 
• 2407-43-4 5-ethyl-5H-furan-2-one 
• 57681-53-5 5-propylfuran-2(5H)-one 
• 21963-26-8 2-nonen-4-olide 

Relevant academic research and scientific papers

An expeditious synthesis of 3-nitropropionic acid and its ethyl and methyl esters

The synthesis to 3-nitropropionic acid 1 was easily accomplished, in two steps, from commercially available acrolein in 60% yield. The ethyl and methyl esters of 1 were also obtained.

SUBSTITUTED PYRROLIDINE AMIDES IV

The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

SUBSTITUTED PYRROLIDINE AMIDES III

The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

Nitroalkylation of alkyl iodides via radical reaction of silyl nitronates

Abstract: Radical reaction of alkyl iodides with phenylsulfonyl substituted silyl nitronates in the presence of hexamethylditin at 300 nm afforded C-alkylated nitro compounds.

A selective method for the preparation of aliphatic methyl esters in the presence of aromatic carboxylic acids

2,2-Dimethoxypropane, methanol and a catalytic amount of HCl selectively esterify aliphatic carboxylic acids, in the presence of aromatic carboxylic acids, at room temperature and in high yields.

Doubly Deprotonated Methyl 3-Nitropropanoate, an Acrylic Ester d2-Reagent

Methyl 3-nitropropanoate can be doubly deprotonated with LDA, both in the α-nitro and in the α-carbonyl position (-> 1).It is shown that the necessary cosolvent HMPT can be replaced by the cyclic urea DMPU, with almost equal results.The new reagent 1 is alkylated and hydroxyalkylated by alkyl halides and aldehydes, respectively, at the 2-position exclusively (see 2, 4, 6, 7).A double alkylation to methyl α,α-dialkyl-β-nitropropanoate 5 is possible.Elimination of HNO2 with DBN or even better with DBU in THF furnishes methyl α-methylenealkanoates 9 and methyl β-hydroxy-α-methylenealkanoates 10.

A NEW SYNTHESIS OF β-NITRO CARBONYL COMPOUNDS FROM ALKYL VINYL KETONES WITH SODIUM NITRITE-ACETIC ACID IN TETRAHYDROFURAN

The reaction of alkyl vinyl ketones with sodium nitrite-acetic acid in THF gave the corresponding β-nitro carbonyl compounds in 42-82percent yield.