(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Base Information

Chemical Name:(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid
CAS No.:1333153-86-8
Molecular Formula:C₁₅H₁₄F₃N₃O₃
Molecular Weight:341.29
Hs Code.:

Synonyms:(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

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Chemical Property of (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

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Technology Process of (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

There total 7 articles about (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

: 1333151-91-9
isopropyl (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

: 1333153-86-8
(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: isopropyl (Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; Product distribution / selectivity;

Reference yield:

: 1333153-42-6
3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazole

: 1333153-86-8
(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0.5 h / 15 °C

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 149793-69-1
3-fluoro-5-trifluoromethyl-benzonitrile

: 1333153-86-8
(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 14 h / 0 - 60 °C

2.1: thionyl chloride / toluene / 90 °C

3.1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 20 °C

4.1: diethyl ether / 20 °C

5.1: N,N-dimethyl-formamide / 2 h / Reflux

6.1: dichloromethane / 0.5 h / 15 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

With thionyl chloride; sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; water; sodium hydride; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;