5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide
CAS No.:1609465-66-8
Molecular Formula:C₂₂H₂₂N₆O₂
Molecular Weight:402.456
Hs Code.:

Synonyms:5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

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Chemical Property of 5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

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Technology Process of 5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

There total 8 articles about 5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 330792-69-3
2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile

: 1609465-65-7
5-amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

: 1609465-66-8
5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / ethanol / 16 h / 55 °C

2: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 16 h / 65 °C

3: sodium hydroxide / ethanol / 0.5 h / 150 °C / Sealed tube

4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

5: methanol / Supercritical conditions

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; In 2-methyltetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1609465-64-6
5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide

: 1609465-65-7
5-amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

: 1609465-66-8
5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: In methanol; Supercritical conditions;

Reference yield:

: 1623-95-6
4-phenoxybenzoyl chloride

: 1609465-65-7
5-amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

: 1609465-66-8
5-amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: triethylamine / ethanol / 16 h / 55 °C

3.1: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 16 h / 65 °C

4.1: sodium hydroxide / ethanol / 0.5 h / 150 °C / Sealed tube

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

6.1: methanol / Supercritical conditions

With palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;