5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide

Base Information

Chemical Name:5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide
CAS No.:1609465-64-6
Molecular Formula:C₂₂H₂₂N₆O₂
Molecular Weight:402.456
Hs Code.:

Synonyms:5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide

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Chemical Property of 5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide

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Technology Process of 5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide

There total 7 articles about 5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 330792-69-3
2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile

: 1609465-64-6
5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethanol / 16 h / 55 °C

2: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 16 h / 65 °C

3: sodium hydroxide / ethanol / 0.5 h / 150 °C / Sealed tube

4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; In 2-methyltetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1609467-45-9
5-amino-3-(4-phenoxyphenyl)-1-piperidin-3-yl-1H-pyrazole-4-carboxylic acid amide

: 590-17-0
cyanomethyl bromide

: 1609465-64-6
5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

Reference yield:

: 1623-95-6
4-phenoxybenzoyl chloride

: 1609465-64-6
5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: triethylamine / ethanol / 16 h / 55 °C

3.1: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 16 h / 65 °C

4.1: sodium hydroxide / ethanol / 0.5 h / 150 °C / Sealed tube

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; N,N-dimethyl-formamide;