1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid

Base Information

Chemical Name:1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid
CAS No.:1616372-40-7
Molecular Formula:C₃₆H₄₃N₃O₄
Molecular Weight:581.755
Hs Code.:

Synonyms:1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid

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Chemical Property of 1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid

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Technology Process of 1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid

There total 12 articles about 1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₂N₄O₂

: 1616372-40-7
1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid

Guidance literature:: With water; potassium hydroxide; In ethylene glycol; at 150 ℃;

Reference yield:

: 1596464-90-2
4-(3-bromophenyl)butanehydrazide

: 1616372-40-7
1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 12 h / 20 °C

2: potassium hydroxide / methanol / 16 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 85 °C / Inert atmosphere

5: potassium hydroxide; water / ethylene glycol / 150 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

: 899350-32-4
4-(3-bromophenyl)-butyric acid

: 1616372-40-7
1-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-ethoxy-[1,1'-biphenyl]-3-yl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: Carbonyldiimidazole / tetrahydrofuran / 1.5 h

1.2: 0.5 h

2.1: tetrahydrofuran / 12 h / 20 °C

3.1: potassium hydroxide / methanol / 16 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 85 °C / Inert atmosphere

6.1: potassium hydroxide; water / ethylene glycol / 150 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Carbonyldiimidazole; water; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethylene glycol; N,N-dimethyl-formamide;