4-CHLORO-N'-(2-CHLOROACETYL)BENZENECARBOHYDRAZIDE

Base Information

• Chemical Name: 4-CHLORO-N'-(2-CHLOROACETYL)BENZENECARBOHYDRAZIDE
• CAS No.: 50677-27-5
• Molecular Formula: C9H8 Cl2 N2 O2
• Molecular Weight: 247.081
• Hs Code.: 2928000090
• Mol file: 50677-27-5.mol

Synonyms:Benzoicacid, 4-chloro-, 2-(chloroacetyl)hydrazide (9CI)

Chemical Property of 4-CHLORO-N'-(2-CHLOROACETYL)BENZENECARBOHYDRAZIDE

Chemical Property:

• Melting Point: 183-184°C
• Boiling Point: 489.7oC at 760 mmHg
• Flash Point: 249.9oC
• PSA: 58.20000
• Density: 1.407g/cm3
• LogP: 2.12160

Purity/Quality:

98%Min ^*data from raw suppliers

4-Chloro-N'-(2-chloroacetyl)benzenecarbohydrazide >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-N'-(2-CHLOROACETYL)BENZENECARBOHYDRAZIDE

There total 6 articles about 4-CHLORO-N'-(2-CHLOROACETYL)BENZENECARBOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-chlorobenzoic acid hydrazide (536-40-3) + chloroacetic acid (79-11-8) → 1-(chloroacetyl)-2-(4-chlorobenzoyl)hydrazine (50677-27-5)

Guidance literature:

chloroacetic acid; With 2,6-dimethylpyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; at 25 ℃; for 0.166667h;

4-chlorobenzoic acid hydrazide; at 20 ℃; for 3h;

DOI:10.1002/ardp.201300240

Reference yield: 82.0%

4-chlorobenzoic acid hydrazide (536-40-3) + chloroacetyl chloride (79-04-9) → 1-(chloroacetyl)-2-(4-chlorobenzoyl)hydrazine (50677-27-5)

Guidance literature:

In acetonitrile; at 20 ℃;

Reference yield: 43.0%

→ 1-(chloroacetyl)-2-(4-chlorobenzoyl)hydrazine (50677-27-5) + 4-chlorobenzoic acid hydrazide (536-40-3)

Guidance literature:

upstream raw materials:

4-chlorobenzoic acid hydrazide

chloroacetyl chloride

ethyl 4-chlorobenzoate

para-chlorobenzoic acid

Downstream raw materials:

3-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-3H-thiazol-2-ylideneamine

1-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-1H-pyridin-2-ylideneamine

1-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-piperidine

4-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-morpholine

Refernces

• 1、 Pokhodylo, Nazariy T.,Savka, Roman D.,Shyyka, Olga Ya.,Obushak, Mykola D.. "One-potCuAAC synthesis of (1H-1,2,3-triazol-1-yl)methyl-1,3,4/1,2,4-oxadiazoles starting from available chloromethyl-1,3,4/1,2,4-oxadiazoles". . p. 2969 - 2976. Retrieved 2020/05/25.
• 2、 -. "CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE". Paragraph 00479-00481. . Retrieved 2019/06/11.