tert-butyl (1R,2R)-3-(tert-butyldimethylsilyloxy)-2-hydroxy-1-(4-(trifluoromethyl)phenyl)propylcarbamate

Base Information

• Chemical Name: tert-butyl (1R,2R)-3-(tert-butyldimethylsilyloxy)-2-hydroxy-1-(4-(trifluoromethyl)phenyl)propylcarbamate
• CAS No.: 944805-01-0
• Molecular Formula: C₂₁H₃₄F₃NO₄Si
• Molecular Weight: 449.586

Synonyms:tert-butyl (1R,2R)-3-(tert-butyldimethylsilyloxy)-2-hydroxy-1-(4-(trifluoromethyl)phenyl)propylcarbamate

Chemical Property of tert-butyl (1R,2R)-3-(tert-butyldimethylsilyloxy)-2-hydroxy-1-(4-(trifluoromethyl)phenyl)propylcarbamate

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Technology Process of tert-butyl (1R,2R)-3-(tert-butyldimethylsilyloxy)-2-hydroxy-1-(4-(trifluoromethyl)phenyl)propylcarbamate

There total 2 articles about tert-butyl (1R,2R)-3-(tert-butyldimethylsilyloxy)-2-hydroxy-1-(4-(trifluoromethyl)phenyl)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl (1R,2R)-2,3-dihydroxy-1-(4-(trifluoromethyl)phenyl)-propylcarbamate (944805-00-9) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl (1R,2R)-3-(tert-butyldimethylsilyloxy)-2-hydroxy-1-(4-(trifluoromethyl)phenyl)propylcarbamate (944805-01-0)

Guidance literature:

tert-butyl (1R,2R)-2,3-dihydroxy-1-(4-(trifluoromethyl)phenyl)-propylcarbamate; With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

tert-butyldimethylsilyl chloride; In N,N-dimethyl-formamide; for 36h;

Reference yield: 95.0%

tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl (1R,2R)-3-(tert-butyldimethylsilyloxy)-2-hydroxy-1-(4-(trifluoromethyl)phenyl)propylcarbamate (944805-01-0)

Guidance literature:

tert-butyl (1R,2R)-2,3-dihydroxy-1-(4-(trifluoromethyl)phenyl)-propylcarbamate; With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

tert-butyldimethylsilyl chloride; In N,N-dimethyl-formamide; for 16h;

Reference yield: 88.0%

tert-butyl (1R,2R)-3-(tert-butyldimethylsilyloxy)-2-hydroxy-1-(4-(trifluoromethyl)phenyl)propylcarbamate (944805-01-0) + methanesulfonyl chloride (124-63-0) → (1R,2R)-1-((tert-butoxycarbonyl)amino)-3-(tert-butyldimethylsilyloxy)-1-(4-(trifluoromethyl)phenyl)propan-2-yl methanesulfonate (944805-02-1)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 20 ℃;

upstream raw materials:

tert-butyldimethylsilyl chloride

tert-butyl (1R,2R)-2,3-dihydroxy-1-(4-(trifluoromethyl)phenyl)-propylcarbamate

Downstream raw materials:

(1R,2R)-1-((tert-butoxycarbonyl)amino)-3-(tert-butyldimethylsilyloxy)-1-(4-(trifluoromethyl)phenyl)propan-2-yl methanesulfonate

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