3-{[(16β,17β)-3-[(dimethylamino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide

Base Information

Chemical Name:3-{[(16β,17β)-3-[(dimethylamino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide
CAS No.:1401937-70-9
Molecular Formula:C₂₉H₃₈N₂O₂
Molecular Weight:446.633
Hs Code.:

Synonyms:3-{[(16β,17β)-3-[(dimethylamino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide

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Chemical Property of 3-{[(16β,17β)-3-[(dimethylamino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide

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Technology Process of 3-{[(16β,17β)-3-[(dimethylamino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide

There total 9 articles about 3-{[(16β,17β)-3-[(dimethylamino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1318265-16-5
(3-{[(16β,17β)-3-(bromomethyl)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide)

: 124-40-3
dimethyl amine

: 1401937-70-9
3-{[(16β,17β)-3-[(dimethylamino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 2455-37-0
(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid

: 1401937-70-9
3-{[(16β,17β)-3-[(dimethylamino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / ethanol; water / 0.5 h / Reflux

2: sodium tetrahydroborate; methanol / dichloromethane / 2 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / Inert atmosphere

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5: carbon tetrabromide; triphenylphosphine / dichloromethane / 5 h / 0 °C

6: triethylamine / dichloromethane / 3 h / 20 °C

With methanol; sodium tetrahydroborate; carbon tetrabromide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 126534-87-0
3-carboxamidobenzaldehyde

: 1401937-70-9
3-{[(16β,17β)-3-[(dimethylamino)methyl]-17-hydroxyestra-1-(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / ethanol; water / 0.5 h / Reflux

2: sodium tetrahydroborate; methanol / dichloromethane / 2 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / Inert atmosphere

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5: carbon tetrabromide; triphenylphosphine / dichloromethane / 5 h / 0 °C

6: triethylamine / dichloromethane / 3 h / 20 °C

With methanol; sodium tetrahydroborate; carbon tetrabromide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;