(E)-(S)-ethyl-1-((1-(3-ethoxy-3-oxoprop-1-en-1-yl)pyrrolidine-2-yl)diphenylmethyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: (E)-(S)-ethyl-1-((1-(3-ethoxy-3-oxoprop-1-en-1-yl)pyrrolidine-2-yl)diphenylmethyl)-1H-1,2,3-triazole
• CAS No.: 1630955-07-5
• Molecular Formula: C₂₇H₃₀N₄O₄
• Molecular Weight: 474.56
• Mol file: 1630955-07-5.mol

Synonyms:(E)-(S)-ethyl-1-((1-(3-ethoxy-3-oxoprop-1-en-1-yl)pyrrolidine-2-yl)diphenylmethyl)-1H-1,2,3-triazole

Chemical Property of (E)-(S)-ethyl-1-((1-(3-ethoxy-3-oxoprop-1-en-1-yl)pyrrolidine-2-yl)diphenylmethyl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (E)-(S)-ethyl-1-((1-(3-ethoxy-3-oxoprop-1-en-1-yl)pyrrolidine-2-yl)diphenylmethyl)-1H-1,2,3-triazole

There total 3 articles about (E)-(S)-ethyl-1-((1-(3-ethoxy-3-oxoprop-1-en-1-yl)pyrrolidine-2-yl)diphenylmethyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-2-(azidodiphenylmethyl)pyrrolidine (1227182-01-5) + propynoic acid ethyl ester (623-47-2) → (E)-(S)-ethyl-1-((1-(3-ethoxy-3-oxoprop-1-en-1-yl)pyrrolidine-2-yl)diphenylmethyl)-1H-1,2,3-triazole (1630955-07-5)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; acetonitrile; at 50 ℃; for 16h; Inert atmosphere;

DOI:10.5012/bkcs.2014.35.6.1605

Reference yield: 78.0%

(E)-(S)-ethyl 3-(2-(azidodiphenylmethyl)pyrrolidin-1-yl)acrylate (1630955-05-3) + propynoic acid ethyl ester (623-47-2) → (E)-(S)-ethyl-1-((1-(3-ethoxy-3-oxoprop-1-en-1-yl)pyrrolidine-2-yl)diphenylmethyl)-1H-1,2,3-triazole (1630955-07-5)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; acetonitrile; at 50 ℃; for 4h; Inert atmosphere;

DOI:10.5012/bkcs.2014.35.6.1605

Reference yield: 29.0%

(S)-2-(azidodiphenylmethyl)pyrrolidine (1227182-01-5) + propynoic acid ethyl ester (623-47-2) → (E)-(S)-ethyl 3-(2-(azidodiphenylmethyl)pyrrolidin-1-yl)acrylate (1630955-05-3) + (S)-ethyl-1-(diphenyl(pyrrolidin-2-yl)methyl)-1H-1,2,3-triazole-4-carboxylate (1630955-06-4) + (E)-(S)-ethyl-1-((1-(3-ethoxy-3-oxoprop-1-en-1-yl)pyrrolidine-2-yl)diphenylmethyl)-1H-1,2,3-triazole (1630955-07-5)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.5012/bkcs.2014.35.6.1605

upstream raw materials:

(E)-(S)-ethyl 3-(2-(azidodiphenylmethyl)pyrrolidin-1-yl)acrylate

propynoic acid ethyl ester

(S)-2-(azidodiphenylmethyl)pyrrolidine