1-[difluoro(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene

Base Information

• Chemical Name: 1-[difluoro(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene
• CAS No.: 196080-81-6
• Molecular Formula: C₁₃H₂₂F₂Si₂
• Molecular Weight: 272.485
• Mol file: 196080-81-6.mol

Synonyms:1-[difluoro(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene

Chemical Property of 1-[difluoro(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-[difluoro(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene

There total 3 articles about 1-[difluoro(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

chloro-trimethyl-silane (75-77-4) + trimethyl(3-(trifluoromethyl)phenyl)silane (4405-40-7) → 1-[difluoro(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene (196080-81-6) + 1-[fluoro-bis(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene (196080-82-7) + 1-[fluoro-bis(trimethylsilyl)methyl]-4-(trimethylsilyl)benzene (1355722-39-2)

Guidance literature:

With Cu-Mg; In desipramine; at 25 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tet.2011.11.082

Reference yield: 82.0%

chloro-trimethyl-silane (75-77-4) + trimethyl(3-(trifluoromethyl)phenyl)silane (4405-40-7) → 1-[difluoro(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene (196080-81-6) + 1-[fluoro-bis(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene (196080-82-7)

Guidance literature:

With magnesium; copper(l) chloride; at 25 ℃; for 5h; chemoselective reaction;

DOI:10.1016/j.jfluchem.2013.02.001

Reference yield:

chloro-trimethyl-silane (75-77-4) + 3-chlorotrifluoromethylbenzene (98-15-7) → α,α,α-trifluorotoluene (98-08-8) + 1-[difluoro(trimethylsilyl)methyl]-3-(trimethylsilyl)benzene (196080-81-6) + trimethyl(3-(trifluoromethyl)phenyl)silane (4405-40-7)

Guidance literature:

With magnesium; In desipramine; at 25 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tet.2011.11.082

upstream raw materials:

chloro-trimethyl-silane

trimethyl(3-(trifluoromethyl)phenyl)silane

3-chlorotrifluoromethylbenzene