4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

Base Information

Chemical Name:4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride
CAS No.:432029-31-7
Molecular Formula:C₂₁H₂₄Cl₂N₄O₃*ClH
Molecular Weight:487.813
Hs Code.:

Synonyms:4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

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Chemical Property of 4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

Chemical Property:

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Technology Process of 4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

There total 10 articles about 4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 432029-32-8
4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide

: 432029-31-7
4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2014.09.059

Reference yield:

: 3-benzyloxy-N-(5-chloro-2-pyridyl)-2-nitrobenzamide

: 432029-31-7
4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: pentamethylbenzene,; trifluoroacetic acid / 23 h / 40 °C

2: hydrogen / ethyl acetate; ethanol / 29 h / 760.05 Torr

3: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C

4: pyridine / 12 h / 0 - 20 °C

5: hydrogenchloride / water; ethanol / 0.5 h / 20 °C

With pyridine; hydrogenchloride; N-chloro-succinimide; pentamethylbenzene,; hydrogen; trifluoroacetic acid; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.09.059

Reference yield:

: 280771-97-3
1-(1-methylethyl)-4-piperidine carboxylic acid

: 432029-31-7
4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethyl-formamide / 0.5 h / 80 °C

2: pyridine / 12 h / 0 - 20 °C

3: hydrogenchloride / water; ethanol / 0.5 h / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; N,N-dimethyl-formamide; In ethanol; water;
DOI:10.1016/j.bmc.2014.09.059