2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide

Base Information

• Chemical Name: 2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide
• CAS No.: 365462-83-5
• Molecular Formula: C₁₂H₉Cl₂N₃O₂
• Molecular Weight: 298.128
• Mol file: 365462-83-5.mol

Synonyms:2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide

Chemical Property of 2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide

There total 5 articles about 2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-amino-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide (365462-81-3) → 2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide (365462-83-5)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 50 ℃; for 2.5h;

DOI:10.1016/j.bmc.2014.09.059

Reference yield:

3-benzyloxy-N-(5-chloro-2-pyridyl)-2-nitrobenzamide → 2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide (365462-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pentamethylbenzene,; trifluoroacetic acid / 23 h / 40 °C

2: hydrogen / ethyl acetate; ethanol / 29 h / 760.05 Torr

3: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C

With N-chloro-succinimide; pentamethylbenzene,; hydrogen; trifluoroacetic acid; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.09.059

Reference yield:

C12H8ClN3O4 → 2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide (365462-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / ethyl acetate; ethanol / 29 h / 760.05 Torr

2: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C

With N-chloro-succinimide; hydrogen; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.09.059

upstream raw materials:

2-amino-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide

3-benzyloxy-2-nitrobenzoic acid

2-nitro-3-benzyloxybenzoyl chloride

Downstream raw materials:

3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7-carboxylic acid [2-(5-chloro-pyridin-2-ylcarbamoyl)-4-chloro-6-hydroxy-phenyl]-amide

4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide hydrochloride

4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide