4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide

Base Information

Chemical Name:4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide
CAS No.:432029-32-8
Molecular Formula:C₂₁H₂₄Cl₂N₄O₃
Molecular Weight:451.353
Hs Code.:

Synonyms:4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide

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Chemical Property of 4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide

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Technology Process of 4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide

There total 6 articles about 4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 365462-83-5
2-amino-5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide

: C₉H₁₆ClNO

: 432029-32-8
4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide

Guidance literature:: With pyridine; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.bmc.2014.09.059

Reference yield:

: 3-benzyloxy-N-(5-chloro-2-pyridyl)-2-nitrobenzamide

: 432029-32-8
4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide

Guidance literature:: Multi-step reaction with 4 steps

1: pentamethylbenzene,; trifluoroacetic acid / 23 h / 40 °C

2: hydrogen / ethyl acetate; ethanol / 29 h / 760.05 Torr

3: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C

4: pyridine / 12 h / 0 - 20 °C

With pyridine; N-chloro-succinimide; pentamethylbenzene,; hydrogen; trifluoroacetic acid; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.09.059

Reference yield:

: C₁₂H₈ClN₃O₄

: 432029-32-8
4'-chloro-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxyl-1-isopropylpiperidine-4-carboxanilide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / ethyl acetate; ethanol / 29 h / 760.05 Torr

2: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C

3: pyridine / 12 h / 0 - 20 °C

With pyridine; N-chloro-succinimide; hydrogen; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.09.059