(4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine

Base Information

• Chemical Name: (4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine
• CAS No.: 1430747-39-9
• Molecular Formula: C₁₃H₂₀ClN₂P
• Molecular Weight: 270.742
• Mol file: 1430747-39-9.mol

Synonyms:(4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine

Chemical Property of (4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine

There total 4 articles about (4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(S)-N2,3,3-trimethyl-N1-phenylbutane-1,2-diamine (1430747-35-5) → (4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine (1430747-39-9)

Guidance literature:

With triethylamine; phosphorus trichloride; In benzene; at 0 ℃; for 0.583333h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetasy.2013.02.010

Reference yield:

aniline (62-53-3) → (4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine (1430747-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

2.2: 0 °C / Inert atmosphere; Reflux

3.1: triethylamine; phosphorus trichloride / benzene / 0.58 h / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; triethylamine; dicyclohexyl-carbodiimide; phosphorus trichloride; In tetrahydrofuran; dichloromethane; benzene;

DOI:10.1016/j.tetasy.2013.02.010

Reference yield:

(S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate (179533-91-6) → (4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine (1430747-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

1.2: 0 °C / Inert atmosphere; Reflux

2.1: triethylamine; phosphorus trichloride / benzene / 0.58 h / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; triethylamine; phosphorus trichloride; In tetrahydrofuran; benzene;

DOI:10.1016/j.tetasy.2013.02.010

upstream raw materials:

(S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate

(S)-N²,3,3-trimethyl-N¹-phenylbutane-1,2-diamine

aniline

N-tert-butyloxycarbonyl-L-tert-leucine

Downstream raw materials:

(4S)-4-tert-butyl-3-methyl-1-phenyl-2-(tricyclo[3.3.1.1.^3′,7′]dec-1′-yloxy)-1,3,2-diazaphospholidine

Refernces