(S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate

Base Information

• Chemical Name: (S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate
• CAS No.: 179533-91-6
• Molecular Formula: C₁₇H₂₆N₂O₃
• Molecular Weight: 306.405
• Mol file: 179533-91-6.mol

Synonyms:(S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate

Chemical Property of (S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate

There total 1 articles about (S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-tert-butyloxycarbonyl-L-tert-leucine (62965-35-9) + aniline (62-53-3) → (S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate (179533-91-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.02.010

Reference yield: 77.0%

(S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate (179533-91-6) → (S)-N2,3,3-trimethyl-N1-phenylbutane-1,2-diamine (1430747-35-5)

Guidance literature:

(S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate; With lithium aluminium tetrahydride; In tetrahydrofuran; for 8h; Inert atmosphere; Reflux;

With water; potassium hydroxide; In tetrahydrofuran; at 0 ℃; Inert atmosphere; Reflux;

DOI:10.1016/j.tetasy.2013.02.010

Reference yield:

(S)-tert-butyl 3,3-dimethyl-1-oxo-1-(phenylamino)butan-2-ylcarbamate (179533-91-6) → (S)-tert-butylglycine phenylamide (171764-05-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1002/jhet.4443

upstream raw materials:

N-tert-butyloxycarbonyl-L-tert-leucine

aniline

Downstream raw materials:

(S)-N²,3,3-trimethyl-N¹-phenylbutane-1,2-diamine

(4S)-4-tert-butyl-2-chloro-3-methyl-1-phenyl-1,3,2-diazaphospholidine

(4S)-4-tert-butyl-3-methyl-1-phenyl-2-(tricyclo[3.3.1.1.^3′,7′]dec-1′-yloxy)-1,3,2-diazaphospholidine

(S)-tert-butylglycine phenylamide

Refernces