(1S,2R,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide

Base Information

Chemical Name:(1S,2R,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide
CAS No.:155320-48-2
Molecular Formula:C₂₄H₃₈N₂O₄
Molecular Weight:418.577
Hs Code.:

Synonyms:(1S,2R,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide

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Chemical Property of (1S,2R,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide

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Technology Process of (1S,2R,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide

There total 1 articles about (1S,2R,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 109-73-9,85404-21-3
N-butylamine

: 153152-97-7
(1S,4S,5R,1'S)-4-(1'-N-tert-butoxycarbonylamino-2'-phenyl)ethyl-3-oxobicyclo<3.3.0>octan-2-one

: 155320-48-2
(1S,2R,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide

Guidance literature:: for 48h; Ambient temperature;
DOI:10.1248/cpb.41.1378

Reference yield: 92.0%

: 116-11-0
2-Methoxypropene

: 155320-48-2
(1S,2R,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide

: 155320-51-7
(4S,5S,1'R,2'S)-4-benzyl-3-N-tert-butoxycarbonyl-5-(2'-n-butylaminocarbonyl)cyclopentyl-2,2-dimethyloxazolidine

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1248/cpb.41.1378

Reference yield:

: 155320-48-2
(1S,2R,1'S,2'S)-2-(2'-tert-butoxycarbonylamino-1'-hydroxy-3'-phenylpropyl)cyclopentane-1-carboxylic acid n-butylamide

: 155320-55-1
(4S,5S,1'R,2'R)-4-benzyl-3-N-tert-butoxycarbonyl-5-(2'-n-butylaminocarbonyl)cyclopentyl-2,2-dimethyloxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / pyridinium p-toluenesulfonate (PPTS) / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 74 percent / tert-BuOK / dimethylformamide; 2-methyl-propan-2-ol / 4 h / 90 °C

With potassium tert-butylate; pyridinium p-toluenesulfonate; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.41.1378