(3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Base Information

Chemical Name:(3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one
CAS No.:955407-50-8
Molecular Formula:C₂₉H₃₂Cl₂N₄O
Molecular Weight:523.505
Hs Code.:

Synonyms:(3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Suppliers and Price of (3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

There total 10 articles about (3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 771-99-3
4-phenylpiperidine

: 955406-17-4
(3R,5S)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 955407-50-8
(3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: 4-phenylpiperidine; (3R,5S)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester; In 1-methyl-pyrrolidin-2-one; at 201 ℃; for 1.5h; microwave irradiation;

With lithium hydroxide; water; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 16h;

Reference yield:

: 1171130-67-8
(3-dimethylaminomethylene-4-oxo-cyclohexyl)-carbamic acid tert-butyl ester

: 955407-50-8
(3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrazine / ethanol / 20 °C

2.1: methanol; hexanes / Resolution of racemate

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: 1,2-dichloro-ethane; isopropyl alcohol / 17 h / 20 °C

4.2: 2 h / 20 °C

4.3: 1 h / 20 °C

5.1: hydrogen / palladium dihydroxide / ethanol / 6 h / 1551.49 Torr

6.1: pyridine / 3.01 h / 0 - 20 °C

7.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 201 °C / microwave irradiation

7.2: 16 h / 20 °C

With pyridine; hydrogen; trifluoroacetic acid; hydrazine; palladium dihydroxide; In 1-methyl-pyrrolidin-2-one; methanol; hexanes; ethanol; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 955373-73-6
(R)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 955407-50-8
(3R,5S)-3-[2,6-dichloro-4-(4-phenyl-piperidin-1-yl)-benzyl]-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,2-dichloro-ethane; isopropyl alcohol / 17 h / 20 °C

1.2: 2 h / 20 °C

1.3: 1 h / 20 °C

2.1: hydrogen / palladium dihydroxide / ethanol / 6 h / 1551.49 Torr

3.1: pyridine / 3.01 h / 0 - 20 °C

4.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 201 °C / microwave irradiation

4.2: 16 h / 20 °C

With pyridine; hydrogen; palladium dihydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; 1,2-dichloro-ethane; isopropyl alcohol;