(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal

Base Information

Chemical Name:(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal
CAS No.:1270942-80-7
Molecular Formula:C₂₅H₃₁NO₇
Molecular Weight:457.524
Hs Code.:

Synonyms:(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal

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Chemical Property of (2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal

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Technology Process of (2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal

There total 8 articles about (2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1270942-79-4
4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane

: 1270942-80-7
(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal

Guidance literature:: With periodic acid; In ethyl acetate; at 25 ℃; for 0.666667h;
DOI:10.1021/ol200160p

Reference yield:

: 1270942-78-3
(3S,4R,5Z)-6-bromo-4-(4-methoxybenzyloxy)-3,5-dimethylhex-5-ene-1,2-diol

: 1270942-80-7
(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / dichloromethane / 17 h / 25 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / tetrahydrofuran; water / 25 h / 50 °C / Inert atmosphere; Sealed tube

3: periodic acid / ethyl acetate / 0.67 h / 25 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; pyridinium p-toluenesulfonate; periodic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 2: Suzuki coupling;
DOI:10.1021/ol200160p

Reference yield:

: 1270942-93-2
2,5-dimethoxy-1-nitro-3-vinylbenzene

: 1270942-80-7
(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-2,4-dimethyl-hept-4-enal

Guidance literature:: Multi-step reaction with 3 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-ethane; toluene / 14 h / 25 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / tetrahydrofuran; water / 25 h / 50 °C / Inert atmosphere; Sealed tube

3: periodic acid / ethyl acetate / 0.67 h / 25 °C

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; periodic acid; 1,2-bis-(diphenylphosphino)ethane; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate; 1,2-dichloro-ethane; toluene; 1: Suzuki-Miyaura coupling / 2: Suzuki coupling;
DOI:10.1021/ol200160p