4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane

Base Information

Chemical Name:4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane
CAS No.:1270942-79-4
Molecular Formula:C₂₉H₃₉NO₈
Molecular Weight:529.631
Hs Code.:

Synonyms:4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane

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Chemical Property of 4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane

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Technology Process of 4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane

There total 6 articles about 4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1270942-88-5
4-[(2R,3R,4Z)-5-bromo-3-(4-methoxybenzyloxy)-4-methylpent-4-en-2-yl]-2,2-dime-thyl-1,3-dioxolane

: 1270942-89-6
2-(2,5-dimethoxy-3-nitrophenethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1270942-79-4
4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide; In tetrahydrofuran; water; at 50 ℃; for 25h; Inert atmosphere; Sealed tube;
DOI:10.1021/ol200160p

Reference yield:

: 1270942-78-3
(3S,4R,5Z)-6-bromo-4-(4-methoxybenzyloxy)-3,5-dimethylhex-5-ene-1,2-diol

: 1270942-79-4
4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / dichloromethane / 17 h / 25 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / tetrahydrofuran; water / 25 h / 50 °C / Inert atmosphere; Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; pyridinium p-toluenesulfonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; 2: Suzuki coupling;
DOI:10.1021/ol200160p

Reference yield:

: 1270942-93-2
2,5-dimethoxy-1-nitro-3-vinylbenzene

: 1270942-79-4
4-[(2R,3R,4Z)-7-(2,5-dimethoxy-3-nitrophenyl)-3-(4-methoxybenzyloxy)-4-methyl-hept-4-en-2-yl]-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,2-bis-(diphenylphosphino)ethane / 1,2-dichloro-ethane; toluene / 14 h / 25 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydroxide / tetrahydrofuran; water / 25 h / 50 °C / Inert atmosphere; Sealed tube

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,2-bis-(diphenylphosphino)ethane; sodium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane; toluene; 1: Suzuki-Miyaura coupling / 2: Suzuki coupling;
DOI:10.1021/ol200160p