4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide

Base Information

Chemical Name:4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide
CAS No.:957345-77-6
Molecular Formula:C₂₁H₁₉BrN₆O₂
Molecular Weight:467.325
Hs Code.:

Synonyms:4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide

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Chemical Property of 4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide

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Technology Process of 4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide

There total 3 articles about 4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957344-74-0
5,8-dibromoimidazo[1,2-a]pyrazine

: 959756-39-9
4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide

: 957345-77-6
4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide

Guidance literature:: With hydrogen bromide; In water; isopropyl alcohol; for 24h; Heating / reflux;

Reference yield:

: 56622-54-9
C-(6-methylpyridin-3-yl)methylamine

: 957345-77-6
4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol; ethyl acetate / 0.33 h / Heating / reflux

3.1: hydrogen bromide / water; isopropyl alcohol / 24 h / Heating / reflux

With 4-methyl-morpholine; hydrogen bromide; ammonium formate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; palladium 10% on activated carbon; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 959756-38-8
2-methoxy-N-(6-methylpyridin-3-yl)methyl-4-nitrobenzamide

: 957345-77-6
4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate / palladium 10% on activated carbon / ethanol; ethyl acetate / 0.33 h / Heating / reflux

2: hydrogen bromide / water; isopropyl alcohol / 24 h / Heating / reflux

With hydrogen bromide; ammonium formate; palladium 10% on activated carbon; In ethanol; water; ethyl acetate; isopropyl alcohol;