4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide

Base Information

• Chemical Name: 4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide
• CAS No.: 959756-39-9
• Molecular Formula: C₁₅H₁₇N₃O₂
• Molecular Weight: 271.319
• Mol file: 959756-39-9.mol

Synonyms:4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide

Chemical Property of 4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide

There total 2 articles about 4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-N-(6-methylpyridin-3-yl)methyl-4-nitrobenzamide (959756-38-8) → 4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide (959756-39-9)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 0.333333h; Heating / reflux;

Reference yield:

C-(6-methylpyridin-3-yl)methylamine (56622-54-9) → 4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide (959756-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol; ethyl acetate / 0.33 h / Heating / reflux

With 4-methyl-morpholine; ammonium formate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; palladium 10% on activated carbon; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

5,8-dibromoimidazo[1,2-a]pyrazine (957344-74-0) + 4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide (959756-39-9) → 4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide (957345-77-6)

Guidance literature:

With hydrogen bromide; In water; isopropyl alcohol; for 24h; Heating / reflux;

upstream raw materials:

2-methoxy-N-(6-methylpyridin-3-yl)methyl-4-nitrobenzamide

C-(6-methylpyridin-3-yl)methylamine

Downstream raw materials:

4-(5-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-2-methoxy-N-(6-methylpyridin-3-ylmethyl)benzamide

4-(5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-2-methoxy-N-[(6-methyl-pyridin-3-yl)methyl]benzamide