Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-

Base Information

• Chemical Name: Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-
• CAS No.: 929-75-9
• Deprecated CAS: 79687-29-9
• Molecular Formula: C8H20 N2 O3
• Molecular Weight: 192.258
• Hs Code.: 29221990
• European Community (EC) Number: 213-206-2
• UNII: 6LRZ526LFU
• DSSTox Substance ID: DTXSID6074334
• Nikkaji Number: J298.508J
• Wikidata: Q72463118
• Mol file: 929-75-9.mol

Synonyms:929-75-9;Amino-PEG3-Amine;1,11-Diamino-3,6,9-trioxaundecane;Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-;3,6,9-Trioxaundecane-1,11-diamine;(PEO)4-bis-amine;2,2'-((oxybis(ethane-2,1-diyl))bis(oxy))diethanamine;Amino-PEG3-C2-Amine;3,6,9-Trioxaundecamethylenediamine;H2N-PEG3-CH2CH2NH2;2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanamine;C8H20N2O3;MFCD00628164;2,2'-[Oxybis(ethylenoxy)]diethylamine;6LRZ526LFU;2,2'-((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethan-1-amine);EINECS 213-206-2;Ethanamine, 2,2'-(oxybis(2,1-ethanediyloxy))bis-;1,11-Diamino-3,6,9-trioxaundecan;2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethan-1-amine;NH2-PEG2-NH2;NH2-PEG3-NH2;CBDivE_003587;UNII-6LRZ526LFU;SCHEMBL202447;LCZC1770;DTXSID6074334;BCP30520;EX-A3893;Bis[2-(2-aminoethoxy)ethyl] Ether;1.11-diamino-3,6,9-trioxaundecane;AKOS002313321;CS-W015804;HY-W015088;1,11-Diamino-3,6,9-trioxa-undecane;BP-20571;CS-13076;SY052959;D3664;DIETHYLENE GLYCOL BIS(AMINOETHYL) ETHER;EN300-314368;H11423;A859901;(R)-(+)-2-(PHENYLCARBAMOYLOXY)PROPIONICACID;2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-1-ethanamine;1,11-Diamino-3,6,9-trioxaundecane, >=98.0% (GC);3,6,9-trioxaundecamethylenediamine pound>>Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis- pound>>2,2'-((oxybis(ethane-2,1-diyl))bis(oxy))diethanamine

Chemical Property of Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-

Chemical Property:

• Vapor Pressure: 0.00199mmHg at 25°C
• Refractive Index: 1.440
• Boiling Point: 291.1°Cat760mmHg
• PKA: 9.04±0.10(Predicted)
• Flash Point: 131.8°C
• PSA: 79.73000
• Density: 1.027g/cm³
• LogP: 0.35420
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• XLogP3: -2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 192.14739250
• Heavy Atom Count: 13
• Complexity: 83.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,11-Diamino-3,6,9-trioxaundecane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(COCCOCCOCCN)N
• Description: Amino-PEG3-Amine is a PEG crosslinking reagent with two amino groups.The amino (NH2) groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
• Uses: Hydrophilic, homo-bifunctional linker, i.e. for the prep. of biotinylation reagents, for the prep. of dendrimers and for the prep. of macrocycles.

Technology Process of Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-

There total 12 articles about Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Tetraethylene glycol (112-60-7) → 2-[2-[2-[2-aminoethoxy]ethoxy]ethoxy]ethylamine (929-75-9,892154-56-2)

Guidance literature:

With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tert-Amyl alcohol; at 140 ℃; for 20h; Inert atmosphere; Cooling;

Reference yield: 97.0%

→ 2-[2-[2-[2-aminoethoxy]ethoxy]ethoxy]ethylamine (929-75-9,892154-56-2)

Guidance literature:

Reference yield: 93.0%

1,11-diazido-3,6,9-trioxaundecane (101187-39-7,82055-94-5) → 2-[2-[2-[2-aminoethoxy]ethoxy]ethoxy]ethylamine (929-75-9,892154-56-2)

Guidance literature:

With hydrogen; palladium on barium sulfate; In ethanol; water; for 30h; under 760 Torr;

DOI:10.1016/S0040-4039(98)01348-3

upstream raw materials:

1,11-dichloro-3,6,9-trioxaundecane

1,11-diazido-3,6,9-trioxaundecane

2,2'-(2,2'-(2,2'-oxybis(ethan-2,1-diyl)bis(oxy))bis(ethan-2,1-diyl))diisoindolin-1,3-dione

Tetraethylene glycol

Downstream raw materials:

1,3-diaza-6,9,12-trioxacyclotetradecane-2-thione

1,3,15,17-tetraaza-6,9,12,20,23,26-hexaoxacyclooctacosane-2,16-dithione

7,19-dimethyl-21-benzyl-1,4,10,13,16-pentaoxa-7,19-diazacycloheneicosane-2,6,20-trione

Refernces

• 1、 -. "Assisted enzyme replacement therapy". . . Retrieved 2018/03/07.
• 2、 Kimura, Yoshihiko,Miyabara, Yuichiro,Terashima, Takaya,Sawamoto, Mitsuo. "Polyacrylamide pseudo crown ethers via hydrogen bond-assisted cyclopolymerization". . p. 3294 - 3302. Retrieved 2016/09/09.