dimethyl 2-(but-2-yn-1-yl)-2-((1-cyclohexyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

Base Information

• Chemical Name: dimethyl 2-(but-2-yn-1-yl)-2-((1-cyclohexyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate
• CAS No.: 1437300-29-2
• Molecular Formula: C₂₂H₃₁NO₄
• Molecular Weight: 373.492

Synonyms:dimethyl 2-(but-2-yn-1-yl)-2-((1-cyclohexyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

Chemical Property of dimethyl 2-(but-2-yn-1-yl)-2-((1-cyclohexyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

Chemical Property:

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Technology Process of dimethyl 2-(but-2-yn-1-yl)-2-((1-cyclohexyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate

There total 1 articles about dimethyl 2-(but-2-yn-1-yl)-2-((1-cyclohexyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

dimethyl 2,2-di(but-2-yn-1-yl)malonate (107428-05-7) + 1-(1-cyclohexyl)-2-methyleneaziridine (195153-97-0) → dimethyl 2-(but-2-yn-1-yl)-2-((1-cyclohexyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate (1437300-29-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; In 1,4-dioxane; at 20 ℃; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/c3cc41061g

Reference yield: 83.0%

dimethyl 2-(but-2-yn-1-yl)-2-((1-cyclohexyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)malonate (1437300-29-2) → C22H31NO4 (1589546-41-7)

Guidance literature:

With Echavarren's catalyst; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol500744k

upstream raw materials:

dimethyl 2,2-di(but-2-yn-1-yl)malonate

1-(1-cyclohexyl)-2-methyleneaziridine

Downstream raw materials:

C₂₂H₃₁NO₄

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