di-tert-butyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate

Base Information

Chemical Name:di-tert-butyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate
CAS No.:528836-51-3
Molecular Formula:C₃₅H₅₁N₃O₁₄S₂
Molecular Weight:801.934
Hs Code.:

Synonyms:di-tert-butyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate

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Chemical Property of di-tert-butyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate

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Technology Process of di-tert-butyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate

There total 3 articles about di-tert-butyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: di-tert-butyl 4-{N-[4'-bis(2''-hydroxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate

: 7143-01-3
Methanesulfonic anhydride

: 528836-51-3
di-tert-butyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm020462i

Reference yield:

: 180839-20-7
di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

: 528836-51-3
di-tert-butyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 92.5 percent / N,N-dimethyl-acetamide / 20 °C

2: 91 percent / triethylamine trihydrofluoride / tetrahydrofuran / 20 °C

3: 100 percent / 4-N-(dimethylamino)pyridine; Et₃N / CH₂Cl₂ / 20 °C

With dmap; triethylamine trihydrofluoride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm020462i

Reference yield:

: 528836-42-2
di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate

: 528836-51-3
di-tert-butyl 4-{N-[4'-bis(2''-mesyloxyethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / triethylamine trihydrofluoride / tetrahydrofuran / 20 °C

2: 100 percent / 4-N-(dimethylamino)pyridine; Et₃N / CH₂Cl₂ / 20 °C

With dmap; triethylamine trihydrofluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm020462i