di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate

Base Information

Chemical Name:di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate
CAS No.:528836-42-2
Molecular Formula:C₄₅H₇₅N₃O₁₀Si₂
Molecular Weight:874.276
Hs Code.:

Synonyms:di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate

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Chemical Property of di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate

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Technology Process of di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate

There total 7 articles about di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

: 180839-20-7
di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

: 528836-38-6
4-methylamino-N,N-bis[2'-(tert-butyldimethylsilyloxy)ethyl]aniline

: 528836-42-2
di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate

Guidance literature:: In N,N-dimethyl acetamide; at 20 ℃;
DOI:10.1021/jm020462i

Reference yield:

: 18226-17-0
N,N-bis(2-hydroxyethyl)-4-nitroaniline

: 528836-42-2
di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / imidazole / dimethylformamide / 20 h / 20 °C

2.1: 95 percent / H₂ / Pd/C / tetrahydrofuran / 6 h

3.1: 95 percent / tetrahydrofuran / 16 h / 20 °C

4.1: NaH / tetrahydrofuran / 0.67 h / 20 °C

4.2: 100 percent / tetrahydrofuran / 12 h / 20 °C

5.1: 100 percent / H₂ / Pd/C / ethyl acetate / 3 h

6.1: 92.5 percent / N,N-dimethyl-acetamide / 20 °C

With 1H-imidazole; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020462i

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 528836-42-2
di-tert-butyl 4-{[4'-bis(2''-(tert-butyldimethylsilyloxy)ethyl)aminophenyl]-N-methylcarbamoyloxymethyl}phenyloxycarbonyl L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / imidazole / dimethylformamide / 20 h / 20 °C

2.1: 95 percent / H₂ / Pd/C / tetrahydrofuran / 6 h

3.1: 95 percent / tetrahydrofuran / 16 h / 20 °C

4.1: NaH / tetrahydrofuran / 0.67 h / 20 °C

4.2: 100 percent / tetrahydrofuran / 12 h / 20 °C

5.1: 100 percent / H₂ / Pd/C / ethyl acetate / 3 h

6.1: 92.5 percent / N,N-dimethyl-acetamide / 20 °C

With 1H-imidazole; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020462i