Technology Process of (2S,3S,4R)-3,4-Bis-benzyloxy-3,4-dihydro-2H-pyran-2-carbaldehyde
There total 11 articles about (2S,3S,4R)-3,4-Bis-benzyloxy-3,4-dihydro-2H-pyran-2-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
ethyl acetate;
at 75 ℃;
for 4h;
Inert atmosphere;
DOI:10.1039/c2ob25222h
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / imidazole / tetrahydrofuran / 1) 0 deg C, 1 h, 2) rt, 4 h
2: 65 percent / NaH, tetrabutylammonium iodide / tetrahydrofuran / 9 h / Ambient temperature
3: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature
4: pyridinium chlorochromate, 4-Angstroem molecular sieves / CH2Cl2
With
1H-imidazole; 4 A molecular sieve; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00028a033
- Guidance literature:
-
Multi-step reaction with 5 steps
1: methanol; sodium methylate / 3 h / 20 °C
2: 1H-imidazole / tetrahydrofuran / 24 h / 20 °C
3: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 2 h / 20 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / 75 °C / Inert atmosphere
With
1H-imidazole; methanol; tetrabutyl ammonium fluoride; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; ethyl acetate;
DOI:10.1039/c2ob25222h
