Technology Process of 1,5-anhydro-di-O-benzyl-2,6,7-trideoxy-D-arabino-hept-1,6-dienitol
There total 13 articles about 1,5-anhydro-di-O-benzyl-2,6,7-trideoxy-D-arabino-hept-1,6-dienitol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl-triphenylphosphonium iodide;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 1.5h;
Inert atmosphere;
(2S,3S,4R)-3,4-Bis-benzyloxy-3,4-dihydro-2H-pyran-2-carbaldehyde;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1039/c2ob25222h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 65 percent / PDC, molecular sieves 4 Angstroem / CH2Cl2 / 10 h / Ambient temperature
2: 62 percent / NaNH2 / diethyl ether / 0.5 h / Ambient temperature
With
dipyridinium dichromate; 4 A molecular sieve; sodium amide;
In
diethyl ether; dichloromethane;
DOI:10.1039/a801989d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: methanol; sodium methylate / 3 h / 20 °C
2.1: 1H-imidazole / tetrahydrofuran / 24 h / 20 °C
3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 2 h / 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / 75 °C / Inert atmosphere
6.1: potassium hexamethylsilazane / tetrahydrofuran / 1.5 h / -78 - 0 °C / Inert atmosphere
6.2: 3 h / -78 - 20 °C / Inert atmosphere
With
1H-imidazole; methanol; tetrabutyl ammonium fluoride; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; ethyl acetate;
6.2: Wittig reaction;
DOI:10.1039/c2ob25222h
