(R)-ethyl 2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate

Base Information

Chemical Name:(R)-ethyl 2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate
CAS No.:1432669-78-7
Molecular Formula:C₂₃H₂₅Cl₂NO₄
Molecular Weight:450.362
Hs Code.:

Synonyms:(R)-ethyl 2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate

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Chemical Property of (R)-ethyl 2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate

Chemical Property:

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Technology Process of (R)-ethyl 2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate

There total 16 articles about (R)-ethyl 2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-(2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate

: 1432669-78-7
(R)-ethyl 2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate

Guidance literature:: With Chiralcel OD-H; In hexane; isopropyl alcohol; Reagent/catalyst; Solvent;

Reference yield:

: 53994-85-7
(±)-2-(tert-butoxycarbonyl)-2-(4-chlorophenyl)acetic Acid

: 1432669-78-7
(R)-ethyl 2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

5.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

5.2: 3 h / 20 °C / Inert atmosphere

6.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 °C

6.2: 16 h / 0 - 25 °C

7.1: Chiralcel OD-H / isopropyl alcohol; hexane

With sodium tetrahydroborate; sodium hydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 6212-33-5,7292-70-8
2-(4-Chlorophenyl)glycine

: 1432669-78-7
(R)-ethyl 2-((2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholino)pentanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate; sodium hydroxide / 1,4-dioxane; water / 24 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

3.1: tetrahydrofuran / 0 - 20 °C

4.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

6.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C

6.2: 3 h / 20 °C / Inert atmosphere

7.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 0 °C

7.2: 16 h / 0 - 25 °C

8.1: Chiralcel OD-H / isopropyl alcohol; hexane

With sodium tetrahydroborate; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;