S-[(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropyl] ethanethioate

Base Information

Chemical Name:S-[(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropyl] ethanethioate
CAS No.:855959-16-9
Molecular Formula:C₁₇H₁₇N₃OS
Molecular Weight:311.407
Hs Code.:

Synonyms:S-[(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropyl] ethanethioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of S-[(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropyl] ethanethioate

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Technology Process of S-[(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropyl] ethanethioate

There total 8 articles about S-[(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropyl] ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 855959-10-3
(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropan-1-ol

: 507-09-5
tiolacetic acid

: 855959-16-9
S-[(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropyl] ethanethioate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.1002/hlca.200590051

Reference yield:

: 220805-30-1
(S)-4-Benzyl-3-((R)-2-benzyloxymethyl-3-phenyl-propionyl)-oxazolidin-2-one

: 855959-16-9
S-[(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropyl] ethanethioate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / H₂; HCl / Pd/C / ethyl acetate / 6 h / 20 °C / 760 Torr

2.1: 71 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 16 h / 20 °C

3.1: 66 percent / H₂O₂; LiOH*H₂O / tetrahydrofuran; H₂O / 3 h / 0 °C

4.1: (COCl)2 / CH₂Cl₂ / 12 h / 20 °C

4.2: 93 percent / NEt₃ / tetrahydrofuran / 12 h / 20 °C

5.1: 96 percent / AcOH / 2.5 h / 65 °C

6.1: 84 percent / Bu₄NF / tetrahydrofuran / 2.5 h / 20 °C

7.1: 93 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C

With hydrogenchloride; dmap; lithium hydroxide; oxalyl dichloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; acetic acid; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 7.1: Mitsunobu reaction;
DOI:10.1002/hlca.200590051

Reference yield:

: 855958-92-8
(2R)-2-benzyl-3-{[(tert-butyl)(dimethyl)silyl]oxy}propanoic acid

: 855959-16-9
S-[(2S)-2-(1H-imidazo[4,5-c]pyridin-2-yl)-3-phenylpropyl] ethanethioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: (COCl)2 / CH₂Cl₂ / 12 h / 20 °C

1.2: 93 percent / NEt₃ / tetrahydrofuran / 12 h / 20 °C

2.1: 96 percent / AcOH / 2.5 h / 65 °C

3.1: 84 percent / Bu₄NF / tetrahydrofuran / 2.5 h / 20 °C

4.1: 93 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C

With oxalyl dichloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; acetic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; 4.1: Mitsunobu reaction;
DOI:10.1002/hlca.200590051