(2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone

Base Information

• Chemical Name: (2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone
• CAS No.: 1292842-88-6
• Molecular Formula: C₁₈H₁₆O₄
• Molecular Weight: 296.323
• Mol file: 1292842-88-6.mol

Synonyms:(2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone

Chemical Property of (2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone

There total 10 articles about (2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone (1292842-76-2) → (2-ethyl-6-hydroxybenzofuran-4-yl)(4-methoxyphenyl)methanone (1292842-89-7) + (2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone (1292842-88-6) + (2-ethyl-6-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone (1292842-90-0)

Guidance literature:

(2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone; With sodium thioethylate; In N,N-dimethyl-formamide; at 105 - 115 ℃; for 18h;

With water; ammonium chloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm1015022

Reference yield: 46.0%

(2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone (1292842-76-2) → (2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone (1292842-88-6)

Guidance literature:

(2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone; With sodium thioethylate; In N,N-dimethyl-formamide; at 105 - 110 ℃; for 3h;

With water; ammonium chloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm1015022

Reference yield:

2-ethyl-6-methoxybenzofuran (52814-93-4) → (2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone (1292842-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(IV) chloride / carbon disulfide / 5 - 20 °C / Inert atmosphere; Cooling with ice

2: sodium thioethylate / N,N-dimethyl-formamide / 3 h / 105 - 110 °C

With tin(IV) chloride; sodium thioethylate; In carbon disulfide; N,N-dimethyl-formamide;

DOI:10.1021/jm1015022

upstream raw materials:

2-Hydroxy-4-methoxybenzaldehyde

2-ethyl-6-methoxybenzofuran

(2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone

1-(6-methoxybenzofuran-2-yl)ethan-1-one