(2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone

Base Information

• Chemical Name: (2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone
• CAS No.: 1292842-76-2
• Molecular Formula: C₁₉H₁₈O₄
• Molecular Weight: 310.35
• Mol file: 1292842-76-2.mol

Synonyms:(2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone

Chemical Property of (2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone

There total 3 articles about (2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-ethyl-6-methoxybenzofuran (52814-93-4) + 4-methoxy-benzoyl chloride (100-07-2) → (2-ethyl-6-methoxybenzofuran-3-yl)(4-methoxyphenyl)methanone (52814-94-5) + (2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone (1292842-76-2)

Guidance literature:

With tin(IV) chloride; In carbon disulfide; at 5 - 20 ℃; Inert atmosphere; Cooling with ice;

DOI:10.1021/jm1015022

Reference yield:

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) → (2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone (1292842-76-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 6 h / Reflux

2.1: hydrazine / water; diethylene glycol / 120 - 190 °C

2.2: 6 h / 120 - 130 °C

3.1: tin(IV) chloride / carbon disulfide / 5 - 20 °C / Inert atmosphere; Cooling with ice

With tin(IV) chloride; potassium carbonate; hydrazine; In carbon disulfide; water; acetone; diethylene glycol; 1.1: Williamson synthesis / 2.1: Wolff-Kishner reduction;

DOI:10.1021/jm1015022

Reference yield:

1-(6-methoxybenzofuran-2-yl)ethan-1-one (52814-92-3) → (2-ethyl-6-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone (1292842-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine / water; diethylene glycol / 120 - 190 °C

1.2: 6 h / 120 - 130 °C

2.1: tin(IV) chloride / carbon disulfide / 5 - 20 °C / Inert atmosphere; Cooling with ice

With tin(IV) chloride; hydrazine; In carbon disulfide; water; diethylene glycol; 1.1: Wolff-Kishner reduction;

DOI:10.1021/jm1015022

upstream raw materials:

2-Hydroxy-4-methoxybenzaldehyde

2-ethyl-6-methoxybenzofuran

4-methoxy-benzoyl chloride

1-(6-methoxybenzofuran-2-yl)ethan-1-one

Downstream raw materials:

(2-ethyl-6-methoxybenzofuran-4-yl)(4-hydroxyphenyl)methanone

(2-ethyl-6-hydroxybenzofuran-4-yl)(4-methoxyphenyl)methanone

(2-ethyl-6-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone