(S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate
CAS No.:1620056-34-9
Molecular Formula:C₂₆H₂₂BrF₂N₃O₄
Molecular Weight:558.379
Hs Code.:

Synonyms:(S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

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Chemical Property of (S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

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Technology Process of (S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

There total 7 articles about (S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1620056-41-8
(S)-2-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-bromopyridin-3-yl)isoindoline-1,3-dione hydrochloride

: 1620056-34-9
(S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;

Reference yield:

: 186593-43-1
5-amino-3-bromo-2-methylpyridine

: 1620056-34-9
(S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium acetate; acetic acid / Reflux

2: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C

3: copper(II) sulfate / dichloromethane / 2 h / 20 °C

4: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

5: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0 °C

With hydrogenchloride; selenium(IV) oxide; sodium acetate; copper(II) bis(trifluoromethanesulfonate); copper(II) sulfate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 85-44-9
phthalic anhydride

: 1620056-34-9
(S)-tert-butyl 1-(3-bromo-5-(1,3-dioxoisoindolin-2-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium acetate; acetic acid / Reflux

2: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C

3: copper(II) sulfate / dichloromethane / 2 h / 20 °C

4: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C

5: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C

6: triethylamine / dichloromethane / 0 °C

With hydrogenchloride; selenium(IV) oxide; sodium acetate; copper(II) bis(trifluoromethanesulfonate); copper(II) sulfate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane;