1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one

Base Information

Chemical Name:1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one
CAS No.:137965-79-8
Molecular Formula:C₂₄H₃₄N₄O₂
Molecular Weight:410.56
Hs Code.:

Synonyms:1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one

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Chemical Property of 1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one

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Technology Process of 1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one

There total 4 articles about 1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192-58-1
N-methylpyrrole aldehyde

: 137965-79-8
1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 5A molecular sieves, Et₃N / CHCl₃ / 4 h / 25 °C

2: H₂ / PtO₂ / methanol / 35 - 39 Torr

3: 45 percent / toluene / 8 h / Heating

4: 1.) AcOH / 1.) MeOH, H₂O, 25 deg C, 5 min, 2.) MeOH, H₂O, 25 deg C, overnight

With 5A molecular sieve; hydrogen; acetic acid; triethylamine; platinum(IV) oxide; In methanol; chloroform; toluene;
DOI:10.1021/jm00081a018

Reference yield:

: 4-{[1-(1-Methyl-1H-pyrrol-2-yl)-meth-(E)-ylidene]-amino}-butyric acid ethyl ester

: 137965-79-8
1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / PtO₂ / methanol / 35 - 39 Torr

2: 45 percent / toluene / 8 h / Heating

3: 1.) AcOH / 1.) MeOH, H₂O, 25 deg C, 5 min, 2.) MeOH, H₂O, 25 deg C, overnight

With hydrogen; acetic acid; platinum(IV) oxide; In methanol; toluene;
DOI:10.1021/jm00081a018

Reference yield:

: 137965-43-6
4-[(1-Methyl-1H-pyrrol-2-ylmethyl)-amino]-butyric acid ethyl ester

: 137965-79-8
1-{5-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / toluene / 8 h / Heating

2: 1.) AcOH / 1.) MeOH, H₂O, 25 deg C, 5 min, 2.) MeOH, H₂O, 25 deg C, overnight

With acetic acid; In toluene;
DOI:10.1021/jm00081a018