N-{2-[7-(CyclohexylMethyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide

Base Information

Chemical Name:N-{2-[7-(CyclohexylMethyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide
CAS No.:1287785-08-3
Molecular Formula:C₂₂H₂₉NO₂
Molecular Weight:339.478
Hs Code.:
Mol file:1287785-08-3.mol

Synonyms:N-(2-[7-(cyclohexylmethyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

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Chemical Property of N-{2-[7-(CyclohexylMethyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide

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Technology Process of N-{2-[7-(CyclohexylMethyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide

There total 7 articles about N-{2-[7-(CyclohexylMethyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl}acetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1287785-51-6
2-[7-(cyclohexylmethyl)-1,6-dihydro-2H-indeno[5,4-b]furan-8-yl]ethanamine hydrochloride

: 75-36-5
acetyl chloride

: 1287785-08-3
N-(2-[7-(cyclohexylmethyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1021/jm200221q

Reference yield:

: 1287785-42-5
7-(cyclohexylmethyl)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one

: 1287785-08-3
N-(2-[7-(cyclohexylmethyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

1.2: 1 h / 40 °C

2.1: ammonia; hydrogen / ethanol / 72 h / 20 °C

3.1: hydrogenchloride / methanol; ethyl acetate / 3 h / 60 °C

4.1: triethylamine / dichloromethane / 0.17 h / 20 °C

With hydrogenchloride; ammonia; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; mineral oil; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm200221q

Reference yield:

: C₂₀H₂₇NO

: 1287785-08-3
N-(2-[7-(cyclohexylmethyl)-1,6-dihydro-2H-indeno[5,4-b]-furan-8-yl]ethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; ethyl acetate / 3 h / 60 °C

2: triethylamine / dichloromethane / 0.17 h / 20 °C

With hydrogenchloride; triethylamine; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm200221q