6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester

Base Information

• Chemical Name: 6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester
• CAS No.: 250383-35-8
• Molecular Formula: C₂₁H₂₅NO₅
• Molecular Weight: 371.433
• Mol file: 250383-35-8.mol

Synonyms:6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester

Chemical Property of 6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester

There total 2 articles about 6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

→ benzyl (S)-6-(benzyloxycarbonylamino)-2-((2-methyl-1-(3-phenylpropanoylamino)propyl)phosphinoyloxy)hexanoate + 6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester (250383-35-8)

Guidance literature:

Reference yield:

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid (59221-35-1) + benzyl bromide (100-39-0) → 6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester (250383-35-8)

Guidance literature:

With triethylamine; In acetone;

DOI:10.1016/S0040-4039(99)01445-8

Reference yield: 92.0%

6-amino-2(S)-hydroxyhexanoic acid (2279-99-4) + 6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester (250383-35-8) → benzyl 6-benzyloxycarbonylamino-2-((hydroxyphosphinoyl)oxy)hexanoate

Guidance literature:

With anhydrous phosphorus trichloride; In methanol; dichloromethane; chloroform;

upstream raw materials:

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

benzyl bromide

Downstream raw materials:

6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester