6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester

Base Information

• Chemical Name: 6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester
• CAS No.: 250383-22-3
• Molecular Formula: C₂₂H₂₄F₃NO₇S
• Molecular Weight: 503.496
• Mol file: 250383-22-3.mol

Synonyms:6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester

Chemical Property of 6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester

There total 3 articles about 6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

trifluoromethylsulfonic anhydride (358-23-6) + 6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester (250383-35-8) → 6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester (250383-22-3)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm100839w

Reference yield:

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid (59221-35-1) → 6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester (250383-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / acetone

2: lutidine / CH₂Cl₂

With lutidine; triethylamine; In dichloromethane; acetone; 1: Esterification / 2: Acylation;

DOI:10.1016/S0040-4039(99)01445-8

Reference yield:

benzyl bromide (100-39-0) → 6-benzyloxycarbonylamino-(2S)-trifluoromethanesulfonyloxyhexanoic acid benzyl ester (250383-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / acetone

2: lutidine / CH₂Cl₂

With lutidine; triethylamine; In dichloromethane; acetone; 1: Esterification / 2: Acylation;

DOI:10.1016/S0040-4039(99)01445-8

upstream raw materials:

trifluoromethylsulfonic anhydride

6-benzyloxycarbonylamino-(2S)-hydroxyhexanoic acid benzyl ester

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

benzyl bromide