Technology Process of 3-(4-methoxyphenyl)-1-methyl-4-(phenylthio)isoquinoline
There total 4 articles about 3-(4-methoxyphenyl)-1-methyl-4-(phenylthio)isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C25H24O4S;
With
hydrogenchloride; water; ammonium chloride;
In
tetrahydrofuran; ethanol;
at 90 ℃;
for 24h;
Inert atmosphere;
With
ammonium bicarbonate;
In
tetrahydrofuran; ethanol; water;
at 90 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/ol4030309
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / toluene / 18 h / Dean-Stark; Reflux
2.1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium t-butanolate / tetrahydrofuran / 18 h / 70 °C / Inert atmosphere
3.1: sodium t-butanolate / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere
4.1: water; hydrogenchloride; ammonium chloride / tetrahydrofuran; ethanol / 24 h / 90 °C / Inert atmosphere
4.2: 24 h / 90 °C / Inert atmosphere
With
hydrogenchloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); water; ammonium chloride; toluene-4-sulfonic acid; sodium t-butanolate;
In
tetrahydrofuran; ethanol; toluene;
DOI:10.1021/ol4030309
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium t-butanolate / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere
2.1: water; hydrogenchloride; ammonium chloride / tetrahydrofuran; ethanol / 24 h / 90 °C / Inert atmosphere
2.2: 24 h / 90 °C / Inert atmosphere
With
hydrogenchloride; water; ammonium chloride; sodium t-butanolate;
In
tetrahydrofuran; ethanol;
DOI:10.1021/ol4030309
