2-(2-BROMOPHENYL)-2-METHYL-1,3-DIOXOLANE

Base Information

• Chemical Name: 2-(2-BROMOPHENYL)-2-METHYL-1,3-DIOXOLANE
• CAS No.: 50777-64-5
• Molecular Formula: C10H11BrO2
• Molecular Weight: 243.1
• Hs Code.: 2932999099
• Mol file: 50777-64-5.mol

Synonyms:o-Bromoacetophenone ethylene ketal;

Chemical Property of 2-(2-BROMOPHENYL)-2-METHYL-1,3-DIOXOLANE

Chemical Property:

• Vapor Pressure: 0.00296mmHg at 25°C
• Boiling Point: 293.8oC at 760 mmHg
• Flash Point: 129.5oC
• PSA: 18.46000
• Density: 1.433g/cm3
• LogP: 2.66860
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Bromophenyl)-2-methyl-1,3-dioxolane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-BROMOPHENYL)-2-METHYL-1,3-DIOXOLANE

There total 2 articles about 2-(2-BROMOPHENYL)-2-METHYL-1,3-DIOXOLANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromophenyl methyl ketone (2142-69-0) + ethylene glycol (107-21-1) → 2-(2-bromophenyl)-2-methyl-1,3-dioxolane (50777-64-5)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Dean-Stark; Reflux; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01892

Reference yield:

→ 2-(2-bromophenyl)-2-methyl-1,3-dioxolane (50777-64-5)

Guidance literature:

aus o-Bromacetophenon u. Aethylenglykol;

Reference yield: 93.0%

2-(2-bromophenyl)-2-methyl-1,3-dioxolane (50777-64-5) + acetophenone (98-86-2) → 2-(2-(2-methyl-1,3-dioxolan-2-yl)phenyl)-1-phenylethan-1-one

Guidance literature:

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium t-butanolate; In tetrahydrofuran; at 70 ℃; for 18h; Inert atmosphere; Sealed tube;

DOI:10.1039/c5ob02320c

upstream raw materials:

2-bromophenyl methyl ketone

ethylene glycol

Downstream raw materials:

N-(1,1-dimethylethyl)-3-(2-methyl-1,3-dioxolan-2-yl)benzenamine

bis-(3,4-dimethoxy-phenyl)-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-methanol

3,4,5,6-tetrakis-benzyloxy-9-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-9H-xanthen-9-ol

2-[(1',1'-ethylenedioxy)ethyl]benzeneboronic acid

Refernces

• 1、 Itami, Kenichiro,Saito, Yutaro,Segawa, Yasutomo,Yamanoue, Kotono. "Selective Transformation of Strychnine and 1,2-Disubstituted Benzenes by C–H Borylation". supporting information. p. 985 - 993. Retrieved 2020/04/10.
• 2、 Biswal, Pragati,Pati, Bedadyuti Vedvyas,Chebolu, Rajesh,Ghosh, Asit,Ravikumar. "Hydroxylamine-O-Sulfonic Acid (HOSA) as a Redox-Neutral Directing Group: Rhodium Catalyzed, Additive Free, One-Pot Synthesis of Isoquinolines from Arylketones". supporting information. p. 1006 - 1014. Retrieved 2020/02/15.