Methyl 2-chloro-6-fluoro-N-[(4-bromo-3-methyl-2-thiophene)carbonyl]benzenecarboximidothioate

Base Information

• Chemical Name: Methyl 2-chloro-6-fluoro-N-[(4-bromo-3-methyl-2-thiophene)carbonyl]benzenecarboximidothioate
• CAS No.: 265652-40-2
• Molecular Formula: C₁₄H₁₀BrClFNOS₂
• Molecular Weight: 406.727
• Mol file: 265652-40-2.mol

Synonyms:Methyl 2-chloro-6-fluoro-N-[(4-bromo-3-methyl-2-thiophene)carbonyl]benzenecarboximidothioate

Chemical Property of Methyl 2-chloro-6-fluoro-N-[(4-bromo-3-methyl-2-thiophene)carbonyl]benzenecarboximidothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 2-chloro-6-fluoro-N-[(4-bromo-3-methyl-2-thiophene)carbonyl]benzenecarboximidothioate

There total 2 articles about Methyl 2-chloro-6-fluoro-N-[(4-bromo-3-methyl-2-thiophene)carbonyl]benzenecarboximidothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + 4-bromo-3-methyl-2-thiophenecarbonyl chloride (265652-36-6) + 2-chloro-6-fluorobenzenecarbothioamide (769-05-1) → Methyl 2-chloro-6-fluoro-N-[(4-bromo-3-methyl-2-thiophene)carbonyl]benzenecarboximidothioate (265652-40-2)

Guidance literature:

With pyridine; dimethyl sulfate;

Reference yield:

4-bromo-3-methyl-2-thiophenecarbonyl chloride (265652-36-6) + 2-chloro-6-fluorothiobenzimidic acid methyl ester hydrogen bromide (503309-13-5) → Methyl 2-chloro-6-fluoro-N-[(4-bromo-3-methyl-2-thiophene)carbonyl]benzenecarboximidothioate (265652-40-2)

Guidance literature:

2-chloro-6-fluorothiobenzimidic acid methyl ester hydrogen bromide; With 3-Methylpyridine; In 1,4-dioxane; at 20 - 50 ℃; Large scale reaction;

4-bromo-3-methyl-2-thiophenecarbonyl chloride; In 1,4-dioxane; at 10 - 50 ℃; for 3h; Large scale reaction;

DOI:10.1021/op9001577

Reference yield:

Methyl 2-chloro-6-fluoro-N-[(4-bromo-3-methyl-2-thiophene)carbonyl]benzenecarboximidothioate (265652-40-2) + methylhydrazine (60-34-4) → 3-(2-chloro-6-fluorophenyl)-1-methyl-5-(4-bromo-3-methyl-thien-2-yl)-1H-1,2,4-triazole (264257-62-7)

Guidance literature:

In 1,4-dioxane; water;

upstream raw materials:

1,4-dioxane

4-bromo-3-methyl-2-thiophenecarbonyl chloride

2-chloro-6-fluorobenzenecarbothioamide

2-chloro-6-fluorothiobenzimidic acid methyl ester hydrogen bromide

Downstream raw materials:

3-(2-chloro-6-fluorophenyl)-1-methyl-5-(4-bromo-3-methyl-thien-2-yl)-1H-1,2,4-triazole