Befunolol

Base Information

• Chemical Name: Befunolol
• CAS No.: 39552-01-7
• Molecular Formula: C16H21NO4
• Molecular Weight: 291.38
• Hs Code.: 2932999099
• UNII: 418546MT3A
• DSSTox Substance ID: DTXSID80865957
• Nikkaji Number: J16.631F
• Wikipedia: Befunolol
• Wikidata: Q4880388
• NCI Thesaurus Code: C73021
• Metabolomics Workbench ID: 152086
• ChEMBL ID: CHEMBL153984
• Mol file: 39552-01-7.mol

Synonyms:2-acetyl-7-(2-hydroxy-3-isopropylamino)propoxybenzofuran;befunolol;befunolol hydrochloride;Bentos;BFE 60;Glauconex

Chemical Property of Befunolol

Chemical Property:

• Melting Point: 115°
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 433.35°C (rough estimate)
• PSA: 71.70000
• Density: 1.1049 (rough estimate)
• LogP: 2.76400
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly, Heated)
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 291.14705815
• Heavy Atom Count: 21
• Complexity: 347

Purity/Quality:

99% ^*data from raw suppliers

Befunolol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NCC(COC1=CC=CC2=C1OC(=C2)C(=O)C)O
• Uses: Befunolol is a β-adrenergic blocker with an intrinsic sympathomimetic action. But it can work as a β-adrenergic partial agonist in isolated organs. β-Adrenergic blocker used as antiglaucoma agent in ophthalmie solutions
• Therapeutic Function: Beta-adrenergic blocker

Technology Process of Befunolol

There total 10 articles about Befunolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetyl-7-hydroxybenzofuran (40020-87-9) + 1-chloro-3-isopropylaminopropan-2-ol hydrochloride → befunolol (39552-01-7,66685-75-4)

Guidance literature:

With sodium hydroxide; In ethanol; cyclohexane; ethyl acetate; Petroleum ether;

Reference yield:

3-isopropyl-5-(2-acetyl-7-benzofuranoxymethyl)oxazolidone (53943-39-8) → befunolol (39552-01-7,66685-75-4)

Guidance literature:

With sodium hydroxide; In water;

Reference yield:

2-acetyl-7-(2-hydroxy-3-aminopropoxy)benzofuran (39552-12-0) + isopropyl bromide (75-26-3) → befunolol (39552-01-7,66685-75-4)

Guidance literature:

With sodium hydroxide; In hydrogenchloride; methanol;

upstream raw materials:

2-acetyl-7-glycidyloxybenzofuran

isopropylamine

dihydrobufenolol

2-acetyl-7-hydroxybenzofuran potassium salt

Downstream raw materials:

dihydrobufenolol

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