2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine

Base Information

Chemical Name:2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine
CAS No.:1120329-60-3
Molecular Formula:C₄₂H₄₃N₅O₉
Molecular Weight:761.832
Hs Code.:

Synonyms:2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine

Suppliers and Price of 2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

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Technology Process of 2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine

There total 5 articles about 2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1044505-27-2
5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine

: 98-88-4
benzoyl chloride

: 1120329-60-3
2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at -78 ℃; for 1.08333h; Inert atmosphere;
DOI:10.1016/j.bmc.2009.06.045

Reference yield:

: C₃₅H₃₅N₅O₈

: 1120329-60-3
2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / 1,4-dioxane / 1 h / 15 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / -78 °C

With sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; dichloromethane;

Reference yield:

: 81246-83-5
9-(5-O-dimethoxytrityl-β-D-ribofuranosyl)-2-N-isobutyrylguanine

: 1120329-60-3
2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2',3'-secoguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium periodate / 1,4-dioxane; water / 1 h / 15 °C

2: sodium tetrahydroborate / 1,4-dioxane / 1 h / 15 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1 h / -78 °C

With sodium tetrahydroborate; sodium periodate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; dichloromethane; water;