5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

Base Information

Chemical Name:5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole
CAS No.:1350441-98-3
Molecular Formula:C₅₃H₅₃ClN₈O₂S
Molecular Weight:901.575
Hs Code.:

5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

Synonyms:5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

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Chemical Property of 5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

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Technology Process of 5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

There total 8 articles about 5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350440-46-8
5-(3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthiomethyl)-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

: 1350441-98-3
5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

Guidance literature:: 5-(3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthiomethyl)-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole; With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 24h;

Reference yield:

: 1350440-46-8
5-(3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthiomethyl)-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

: 1350441-98-3
5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

: 1350441-99-4
5-[4-hydroxyamino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 4h; Overall yield = 3.35g;

Reference yield:

: 1350440-44-6
5-acetylthiomethyl-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

: 1350441-98-3
5-[4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthiomethyl]-2-butyl-4-chloro-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-dithio-erythritol; morpholine / dichloromethane / 72 h / 20 °C

2.1: sodium hydride; potassium carbonate / N,N-dimethyl-formamide; mineral oil / 7.75 h / 20 - 70 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 4 h / 20 °C

3.2: 24 h / 50 °C

With morpholine; 1,4-dithio-erythritol; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;