2-chloro-N-[5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide

Base Information

• Chemical Name: 2-chloro-N-[5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide
• CAS No.: 1233091-88-7
• Molecular Formula: C₁₀H₆Cl₃N₃OS
• Molecular Weight: 322.602
• Mol file: 1233091-88-7.mol

Synonyms:2-chloro-N-[5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide

Chemical Property of 2-chloro-N-[5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-N-[5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide

There total 4 articles about 2-chloro-N-[5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

chloroacetyl chloride (79-04-9) + 5-(2,4-dichloro-phenyl)-[1,3,4]thiadiazol-2-ylamine (28004-63-9) → 2-chloro-N-[5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide (1233091-88-7)

Guidance literature:

With pyridine; In benzene; at 20 ℃; Reflux;

DOI:10.5012/bkcs.2010.31.8.2345

Reference yield:

(2,4-dichlorobenzylidenehydrazinyl)thiocarboxamide (6957-92-2) → 2-chloro-N-[5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide (1233091-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iron(III) chloride / ethanol / Reflux

2: triethylamine / dichloromethane / 2 h / Reflux

With iron(III) chloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1002/ardp.201400247

Reference yield:

2,4-dichlorobenzaldeyhde (874-42-0) → 2-chloro-N-[5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl]-acetamide (1233091-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / ethanol / Reflux

2: iron(III) chloride / ethanol / Reflux

3: triethylamine / dichloromethane / 2 h / Reflux

With iron(III) chloride; acetic acid; triethylamine; In ethanol; dichloromethane;

DOI:10.1002/ardp.201400247

upstream raw materials:

chloroacetyl chloride

5-(2,4-dichloro-phenyl)-[1,3,4]thiadiazol-2-ylamine

2,4 dichlorobenzoic acid

2,4-dichlorobenzaldeyhde

Downstream raw materials:

5-benzylidene-2-[{5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl}imino]-1,3-thiazolidin-4-one

2-[{5-(2,4-dichlorophenyl)-[1,3,4]-thiadiazol-2-yl}imino]-5-(3,4-dimethoxybenzylidene)-1,3-thiazolidin-4-one

2-[{5-(2,4-dichlorolphenyl)-[1,3,4]-thiadiazol-2-yl}imino]-1,3-thiazolidin-4-one