(2S,4R,6R)-2-ethenyl-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran

Base Information

Chemical Name:(2S,4R,6R)-2-ethenyl-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran
CAS No.:1609536-82-4
Molecular Formula:C₁₈H₂₆O₆
Molecular Weight:338.401
Hs Code.:

Synonyms:(2S,4R,6R)-2-ethenyl-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran

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Chemical Property of (2S,4R,6R)-2-ethenyl-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran

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Technology Process of (2S,4R,6R)-2-ethenyl-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran

There total 7 articles about (2S,4R,6R)-2-ethenyl-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609537-01-0
(2S,4R,6R)-2-(2-iodoethyl)-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)-tetrahydro-2H-pyran

: 1609536-82-4
(2S,4R,6R)-2-ethenyl-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 4h;
DOI:10.1055/s-0033-1340181

Reference yield:

: 1609536-86-8
(2R,4S,6R)-2-[2-(benzyloxy)ethyl]-6-(4-hydroxy-3-methoxyphenyl)tetrahydro-2H-pyran-4-ol

: 1609536-82-4
(2S,4R,6R)-2-ethenyl-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylazodicarboxylate; 4-nitro-benzoic acid; triphenylphosphine / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 4 h / 0 - 20 °C

3.1: lithium; naphthalene / tetrahydrofuran / -20 °C

4.1: triphenylphosphine; iodine; 1H-imidazole / tetrahydrofuran / 4 h / 0 - 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C

With 1H-imidazole; dmap; naphthalene; potassium tert-butylate; iodine; lithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; dichloromethane; 1.1: |Mitsunobu Displacement / 1.2: |Mitsunobu Displacement;
DOI:10.1055/s-0033-1340181

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 1609536-82-4
(2S,4R,6R)-2-ethenyl-6-[3-methoxy-4-(methoxymethoxy)phenyl]-4-(methoxymethoxy)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane

1.2: 4 h / 20 °C

2.1: diethylazodicarboxylate; 4-nitro-benzoic acid; triphenylphosphine / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 4 h / 0 - 20 °C

4.1: lithium; naphthalene / tetrahydrofuran / -20 °C

5.1: triphenylphosphine; iodine; 1H-imidazole / tetrahydrofuran / 4 h / 0 - 20 °C

6.1: potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C

With 1H-imidazole; dmap; naphthalene; potassium tert-butylate; iodine; lithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; dichloromethane; 2.1: |Mitsunobu Displacement / 2.2: |Mitsunobu Displacement;
DOI:10.1055/s-0033-1340181