α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester

Base Information

Chemical Name:α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester
CAS No.:1194752-16-3
Molecular Formula:C₁₄H₁₇F₂NO₄
Molecular Weight:301.29
Hs Code.:

Synonyms:α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester

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Chemical Property of α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester

Chemical Property:

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Technology Process of α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester

There total 4 articles about α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: methyl α-azido-3,5-difluorobenzeneacetate

: 24424-99-5
di-tert-butyl dicarbonate

: 1194752-16-3
α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 18h; under 2585.81 Torr;

Reference yield:

: 210530-70-4
methyl 2-(3,5-difluorophenyl)acetate

: 1194752-16-3
α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 18 h / Inert atmosphere; Reflux

2: sodium azide / acetonitrile / 20.5 h / 20 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / 2585.81 Torr

With N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); hydrogen; palladium 10% on activated carbon; In tetrachloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 557798-60-4
methyl 2-bromo-2-(3,5-difluorophenyl)acetate

: 1194752-16-3
α-(((1,1,-dimethylethoxy)carbonyl)amino)-3,5-difluorobenzeneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / acetonitrile / 20.5 h / 20 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / 2585.81 Torr

With sodium azide; hydrogen; palladium 10% on activated carbon; In ethyl acetate; acetonitrile;