methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate

Base Information

• Chemical Name: methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate
• CAS No.: 1217272-79-1
• Molecular Formula: C₂₂H₂₁N₅O₅
• Molecular Weight: 435.439
• Mol file: 1217272-79-1.mol

Synonyms:methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate

Chemical Property of methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate

There total 3 articles about methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

7-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione (1217272-70-2) + methyl N-(4-bromophenyl)carbamate (25203-36-5) → methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate (1217272-79-1)

Guidance literature:

With copper(l) iodide; palladium diacetate; caesium carbonate; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 40h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol100011n

Reference yield:

theophylline (58-55-9,75448-53-2) → methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate (1217272-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; copper diacetate / dichloromethane / 24 h / 40 °C / Inert atmosphere

2: copper(l) iodide; palladium diacetate; caesium carbonate / N,N-dimethyl-formamide / 40 h / 130 °C / Inert atmosphere

With pyridine; copper(l) iodide; copper diacetate; palladium diacetate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.03.025

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) → methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate (1217272-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; copper diacetate / dichloromethane / 24 h / 40 °C / Inert atmosphere

2: copper(l) iodide; palladium diacetate; caesium carbonate / N,N-dimethyl-formamide / 40 h / 130 °C / Inert atmosphere

With pyridine; copper(l) iodide; copper diacetate; palladium diacetate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.03.025

upstream raw materials:

7-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

methyl N-(4-bromophenyl)carbamate

theophylline

4-methoxyphenylboronic acid

Refernces

• 1、 Kim, Donghee,Jun, Hwiseok,Lee, Hyunseung,Hong, Soon-Sun,Hong, Sungwoo. "Development of new fluorescent xanthines as kinase inhibitors". supporting information; experimental part. p. 1212 - 1215. Retrieved 2010/06/21.