3-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-6-formyl-4,5-dimethyl-benzamide

Base Information

Chemical Name:3-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-6-formyl-4,5-dimethyl-benzamide
CAS No.:182010-02-2
Molecular Formula:C₂₃H₃₇NO₃Si
Molecular Weight:403.637
Hs Code.:

Synonyms:3-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-6-formyl-4,5-dimethyl-benzamide

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Chemical Property of 3-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-6-formyl-4,5-dimethyl-benzamide

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Technology Process of 3-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-6-formyl-4,5-dimethyl-benzamide

There total 7 articles about 3-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-6-formyl-4,5-dimethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58138-52-6
2-hydroxy-4,5-dimethylbenzoic acid

: 182010-02-2
3-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-6-formyl-4,5-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: Li₂CO₃ / dimethylformamide / 2 h / 50 °C

2: NaH / dimethylformamide / 0.5 h / 0 °C

3: 1.) trimethylaluminum / 1.) toluene, benzene, 25 deg C, 1 h, 2.) toluene, benzene, 80 deg C, 24 h

4: N,N-diethylaniline / 4 h / 200 °C

5: 5.66 g / imidazole / dimethylformamide

6: 1.) t-BuLi, TMEDA / 1.) THF, pentane, -90 deg C, 40 min, 2.) THF, pentane, from -90 to -15 deg C

With 1H-imidazole; N,N,N,N,-tetramethylethylenediamine; trimethylaluminum; tert.-butyl lithium; lithium carbonate; sodium hydride; N,N-diethylaniline; In N,N-dimethyl-formamide;
DOI:10.1021/jm9603633

Reference yield:

: 132757-93-8
methyl 2-hydroxy-4,5-dimethylbenzoate

: 182010-02-2
3-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-6-formyl-4,5-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / dimethylformamide / 0.5 h / 0 °C

2: 1.) trimethylaluminum / 1.) toluene, benzene, 25 deg C, 1 h, 2.) toluene, benzene, 80 deg C, 24 h

3: N,N-diethylaniline / 4 h / 200 °C

4: 5.66 g / imidazole / dimethylformamide

5: 1.) t-BuLi, TMEDA / 1.) THF, pentane, -90 deg C, 40 min, 2.) THF, pentane, from -90 to -15 deg C

With 1H-imidazole; N,N,N,N,-tetramethylethylenediamine; trimethylaluminum; tert.-butyl lithium; sodium hydride; N,N-diethylaniline; In N,N-dimethyl-formamide;
DOI:10.1021/jm9603633

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 182010-02-2
3-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-6-formyl-4,5-dimethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 5.66 g / imidazole / dimethylformamide

2: 1.) t-BuLi, TMEDA / 1.) THF, pentane, -90 deg C, 40 min, 2.) THF, pentane, from -90 to -15 deg C

With 1H-imidazole; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In N,N-dimethyl-formamide;
DOI:10.1021/jm9603633