58138-52-6

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Dimethylsalicylic acid is used as a key intermediate for the preparation of 4,5-Dimethylaspirin, which possesses antipyretic (fever-reducing) and analgesic (pain-relieving) activities similar to those of aspirin. This makes it a valuable compound in the development of medications aimed at treating pain and reducing fever.

InChI:InChI=1/C9H10O3/c1-5-3-7(9(11)12)8(10)4-6(5)2/h3-4,10H,1-2H3,(H,11,12)

Upstream product

• 496-78-6 2,4,5-trimethylphenol 
• 95-65-8 3,4-Dimethylphenol 
• 558-13-4 carbon tetrabromide 
• 56-23-5 tetrachloromethane 
• 95646-19-8 3-(2-Hydroxy-4,5-dimethyl-benzoyl)-2-p-tolyl-2,3-dihydro-isoindol-1-one 
• 91061-36-8 2-methoxy-4,5-dimethylbenzoic acid 
• 3453-84-7 2,4,5-trimethylbenzenesulfonic acid 
• 71321-29-4 2-Hydroxy-2-(2-hydroxy-4,5-dimethyl-phenyl)-indan-1,3-dione 
• 36436-65-4 2-acetyl-4,5-dimethylphenol 
• 619-04-5 3,4-dimethylbenzoic acid 
• 91969-74-3 2'-methoxy-4',5'-dimethylacetophenone 
• 22618-23-1 3,4-dimethylphenyl acetate 
• 1666-03-1 4,5-dimethylsalicylaldehyde 

Downstream Products

• 132757-93-8 methyl 2-hydroxy-4,5-dimethylbenzoate 
• 860508-47-0 3-bromo-2-hydroxy-4,5-dimethyl-benzoic acid 
• 57536-07-9 2-hydroxy-4,5-dimethyl-benzoic acid phenyl ester 
• 95-65-8 3,4-Dimethylphenol 
• 124-38-9 carbon dioxide 

Relevant academic research and scientific papers

Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids

A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.

PD(II)-CATALYZED HYDROXYLATION OF ARENES WITH O2 OR AIR

Pd (II) -catalyzed ortho-hydroxylat ion of variously substituted aromatic carboxylic acids under O2 or air is achieved under non-acidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.

Pd(II)-catalyzed hydroxylation of arenes with 1 atm of O2 or air

(Chemical Equation Presented) Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under 1 atm of O2 or air is achieved under nonacidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.

Reimer-Thiemann reaction using carbon tetrachloride

The title reaction has been carried out on the three isomeric cresols, thymol and 3,4-dimethylphenol, and the phenolic carboxylic acids so obtained have been characterised.